Patient Zero is meant to be a prequel to the Global Infection start, showing the scientist who created the shrinking formula and what happens to him as his assistant is there with him to test it.

Working late in the laboratory, Gary thinks that he had finally perfected the shrinking serum. It had been his goal for a long time and he had put many long hours into developing it. Coming into the room, his assistant Hailey, a smart and beautiful y*ung woman, tells him that she is wrapping things up for the day. Before she can leave though, Gary tells her about how he had completed the solution. Instead of leaving, Hailey insists on trying it out, offering her help to record observations. Excited to finally try it out, the scientist doesn't hesitate as he drinks the liquid quickly. However, instead of only shrinking a few inches as he thought, he starts to feel strange, dwindling down to the size of a doll.

Afterwards Gary found himself naked on a stool, he opens his eyes to find his assistant towering above him. She is in a position of power now, suggesting that they take notes on the effects before giving Gary the other solution to help grow himself back. Knowing that this was the best thing to do, he agreed and Hailey sat down with a laptop to begin asking her boss a series of questions. As she does this though, the shrunken man finds himself distracted as he watches his assistant dangle her flat in the corner of his eye. Hailey eventually puts her feet up on the same stool that he was on and Gary can't help but become aroused, proceeding to stroke himself to this sight as the smell clouded his mind. Eventually Hailey notices that something was up and catches the l*ttle man in the act.

Gary tried to play it off as if he were just cold, but the giantess knew what she saw, demanding him to stop covering himself with his hands. Seeing that the shrunken man was hard as a rock, Hailey is shocked. She never thought that her boss would be such a p*rvert, but Gary tries to act as if the reaction was involuntary due to the shrinking. It didn't matter if that was true or not though as Hailey uses this to her advantage, stripping herself down to her underwear and ordering the l*ttle guy to continue where he left off. She teases him with her sexy body as Gary is unable to look away, sliding his fingers across his shaft. Things get taken to the next level as Hailey drops her chest down on him, stimulating his body between her boobs and finally getting up to sit down right on top of him. Eventually Gary can't take it anymore and explodes underneath her dominate *ss.

Upon climaxing, the l*ttle guy started to shrink again, this time down to only a few inches tall. When Hailey got off him she was surprised to see this, telling her boss about some of the side effects of the serum that he might not of known about. Gary demands the growth formula now and she agreed to give it to him. However, since the scientist rushed into this, he made a major mistake. The serum to restore himself back to normal wasn't ready yet, only the solution to stop him from shrinking further. Once he is given this chemical, Gary learns that he would be stuck this way forever, or until the real growth serum would be invented. Wanting to test out if everything worked though, Hailey thought of a great idea, bl*wing Gary off his chair and onto the hard floor.

Hailey's footsteps boomed as she approached the tiny man on the ground. Lifting one foot up, she brought it down on him hard, demonstrating his new durability in his new form. Luckily for Gary, he was unhurt, but at the same time he was aroused once again. Using just her feet, Hailey found amusement in j*rking off her shrunken boss once again, but this time with her sweaty foot. It didn't matter how much Gary squirmed, he was easily dominated as his body surrendered to the pleasure his assistant was bringing him. In no time, he was brought to another *rgasms, only to not shrink again afterwards. It appeared that the serum had worked, but the problem was that he was still tiny and under the control of this girl.

To end the day, Hailey picked up the tiny man and told him that she planned on keeping him this way. With Gary out of the way, she would have access to the shrinking serum to use it however she wanted. Pulling the band of her underwear forward, she dropped the tiny man into it, sealing him shut tightly against her v*gina as she put the rest of her clothes back on. From there, Hailey left the laboratory as if it were a normal day, bringing her shrunken boss home with her. She thought of ways to change the world by developing this serum into a virus that would infect men and reduce them of all of their power.

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